Grape Seed

Grape Seed Grapeseed

(Vitis vinifera)

Used as an antioxidant and in the relief of allergies and asthma; has been known to improve circulation and capillary fragility; has anti-inflammatory properties and has been used for arterial/venous insufficiency (intermittent claudication, varicose veins) and antiplatelets block aggregation.

Maffei Facino, 1997, Frankel, 1993, Jonadet, 1983

Standardized: 95% standardized extract containing Proanthocyanidins 47.5mg
1 capsule with water 2 x daily

Whole Herb: (Grape skin powder) 425mg
1 capsule with water 3 x daily

Summary:

Grape Seed is a source of potent free radical scavengers (antioxidants). It has been used in allergic disorders, including asthma and has been used in a variety of vascular complaints such as varicose veins and peripheral vascular disease.

Pharmacology:
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Grape Seed is a potent antioxidant with the constituent Proanthocyanidins claiming to neutralize many free radicals, including hydroxyl, lipid peroxides, and iron-induced lipid peroxidation. The antioxidant properties of proanthocyanidins are believed to block lipid peroxidation, stabilizing cell membranes. Proanthocyanidins may also inhibit the destruction of collagen, possibly by stabilizing 1-antitrypsin, which inhibits the activity of destructive enzymes such as elastin and hyaluronic acid. Stabilization of collagen is claimed to allow red blood cells to transverse the capillaries and prevent fluid exudation. Proanthocyanidins have been reported to inhibit the release of mediators of inflammation, such as histamine and prostaglandins, and have been used in individuals with allergies. Grape Seed extract may inhibit platelet aggregation.

Theoretical Cautions and Contraindications:

Grape Seed may inhibit platelet aggregation and is contraindicated in individuals with active bleeding (e.g., peptic ulcer, intracranial bleeding). Use with caution in individuals with a history of bleeding, hemostatic disorders, or drug-related hemostatic problems and in individuals taking anticoagulant medications, including warfarin, aspirin, aspirin-containing products, NSAIDs, or antiplatelet agents (e.g., ticlopidine, clopidogrel, dipyridamole). Discontinue use for at least 14 days prior to dental or surgical procedures. In vitro studies indicate Grape Seed may inhibit xanthine oxidase and may increase toxicity of methotrexate.

Theoretical Interactions:

Anticoagulants, aspirin, aspirin-containing products, NSAIDs, antiplatelet agents, xanthine oxidase inhibitors.

References:

Frankel EN, Kanner J, German JB, et al, "Inhibition of Oxidation of Human Low-Density Lipoprotein by Phenolic Substances in Red Wine," Lancet, 1993, 341(8843): 454-7.

Jonadet M, Meunier MT, Basyide J, et al, "Anthocyanosides Extracted From Vitis vinifera, Vaccinium myrtillus and Pinus maritimus. I. Elastase-Inhibiting Activities In Vitro. II. Compared Angioprotective Activities In Vitro," J Pharm Belg, 1983, 38(1): 41-6.

Maffei Facino R, Carini M, Aldini G, et al, "Regeneration of Endogenous Antioxidants, Ascorbic Acid, Alpha Tocopheral, by the Oligomeric Procyanide Fraction of Vitus vinifera L: ESR Study," Boll Chim Farm, 1997, 136(4):310-4.

Short, R. (ed.), "Clinical Considerations for Specific Herb-Drug Interactions & Potential Adverse Effects of Herbs", Facts and Comparisons The Review of Natural Products, St. Louis (Mo), 1998 Dec; 1-8.

Fetrow, C.W., Avila, J. R., Complementary & Alternative Medicines, Springhouse, PA, 1999.

LaValle, J.B., Krinsky, D.L., Hawkins, E.B, et. al., Natural Therapeutics Pocket Guide, Lexi-Comp, USA, 2000.

Gruenwald, J., Brendler, T., Jaenicke, C., PDR for Herbal Medicines, 2nd Ed., Medical Economics Company, NJ, 2000.

Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (eds.) The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Klein S, Rister RS, translators. Austin (TX): American Botanical Council; Boston (MA): Integrative Medicine Communications; 1998.

This information is not intended to diagnose, treat, cure, or prevent any disease. Material herein is derived from journals, textbooks, news releases, reference guides, etc. Graham Development, Inc. cannot be held responsible for the validity of the information contained in any reference noted herein or for the misuse of information or any adverse effects by use of any stated materials presented. ©2000 Scientific Herbals-unauthorized reproduction of this document is prohibited.

Grapeseed Standardized Herbal Supplement 11.99

Grape Powder Herbal Supplement 500 mg 11.29

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