Glucosamine-Boswellia

Glucosamine-Boswellia

(Glucosamine/Boswellia serrata)

Antiarthritic and anti-inflammatory agent for osteoarthritis and other joint disorders.

Ammon, 1996, Beren, 2000, Das, 1999, Houpt, 1999, Leffler, 1999, McCarty, 1994, Phillipi, 1999, Shankland, 1998, Vaz, 1982

Standardized: 500 mg Glucosamine 65% standardized extract containing 195mg Boswellic Acids
1 Capsule with food 3 x daily

Pharmacology:

Glucosamine is an amino-sugar (mucopolysaccharides, mucoproteins, and chitin) that is naturally produced in humans and is synthetically manufactured. It is involved in the synthesis of glycolipids, glycoproteins, hyaluronic acid, proteoglycans, and glycosaminoglycans which are the major structural components of cartilage. The administration of glucosamine is believed to stimulate the production of cartilage and allow rebuilding of damaged cartilage. It has been suggested that Boswellia is effective in the management of arthritis. Its Boswellic Acids have an anti-inflammatory action. Boswellia inhibits pro-inflammatory mediators in the body, such as leukotrienes. Long term use of boswellia does not lead to irritation or ulceration of the stomach as do NSAIDs.

Theoretical Cautions and Contraindications:

No known contraindications. Avoid use in pregnant or breast-feeding women and in children. May cause mild gastrointestinal discomfort or stomach upset, constipation, diarrhea, drowsiness, headache, heartburn and rash.

Theoretical Interactions:

Insulin or oral hypoglycemics may be less effective and glucose levels in diabetic patients should be monitored.

References:

Abimbola O., Adebowale A, Cox D, Liang Z, Eddington N. "Analysis of Glucosamine and Chondroitin Sulfate Content in Marketed Products and the Caco-2 Permeability of Chondroitin Sulfate Raw Materials." JANA, Spring 2000; 3(1); 37-44.

Ammon HP, "Lalai Guggal—Boswellia serrata: From an Herbal Medicine to a Non-redox Inhibitor of Leukotriene Biosyntheses," Eur J Med Res, 1996, 1(8): 369-70.

"Boswellia serrata," Altern Med Rev, 1998, 3(4): 306-7.

Das AK, Eitel J, Hammad TA. "Efficacy of a new class of agents (glucosamine hydrochloride and chondroitin sulfate) in the treament of osteroarthritis of the knee." Paper # 180 presented at eh 66^th annual meeting, American Academy of Orthopedic Surgeons, Ahaheim, Calif, February 6, 1999. Accepted for publication in Osteoarthritis & Cartilage.

Fetrow C., Avila J. Professional’s Handbook of Complementary &Alternative Medicines Springhouse 1999.

Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med February 1999; 164:2:85-91.

Houpt J, McMillan R, Wein C. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of Rheumatology 1999; 26:2433-2430.

Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD.

McCarty, M.F., "Vascular Heparan Sulfates May Limit the Ability of Leukocytes to Penetrate the Endothelial Barrier—Implications for Use of Glucosamine in Inflammatory Disorders," Med Hypotheses, 1998, 51(1):11-15.

McCarty, M.F., "The Neglect of Glucosamine as Treatment for Osteoarthritis," Med Hypotheses, 42:323-27, 1994.

Phillipi A.F., Leffler C.T., Leffler S.G., et al, "Glucosamine, Chondriotin, and Manganese Ascorbate for Degenerative Joint Disease of the Knee or Low Back: A Randomized, Double-Blind, Placebo-Controlled Study," Military Medicine, 1999, 164:85-91.

Shankland, W.E., 2^nd, "The Effects of Glucosamine and Chondroitin Sulfate on Osteorarthritis of the TMJ: A Preliminary Report of 50 Patients," Cranio, 1998, 16(4): 230-5.

LaValle, J.B., Krinsky, D.L., Hawkins, E.B, et. al., Natural Therapeutics Pocket Guide, Lexi-Comp, USA, 2000.

This information is not intended to diagnose, treat, cure, or prevent any disease. Material herein is derived from journals, textbooks, news releases, reference guides, etc. Graham Development, Inc. cannot be held responsible for the validity of the information contained in any reference noted herein or for the misuse of information or any adverse effects by use of any stated materials presented. ©2000 Scientific Herbals-unauthorized reproduction of this document is prohibited.

Glucomsamine HCL 500 mg & Boswellia extract 21.49
Glucomsamine HCL 500 mg & Boswellia extract 21.49

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