Green Tea References
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TITLE: Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. AUTHOR: Ahmad N; Feyes DK; Nieminen AL; Agarwal R; Mukhtar H. AUTHOR AFFILIATION: Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. SOURCE: J Natl. Cancer Inst. 1997 DEC 17;89(24):1881-6NLM CIT. ID: 98074987 (abstract present)
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TITLE: Chemoprevention of aerodigestive cancer. AUTHOR: Berwick M; Schantz S. AUTHOR AFFILIATION: Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. SOURCE: Cancer Metastasis Rev 1997 Sep-Dec;16(3-4):329-47NLM CIT. ID: 98095441 (abstract present)
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TITLE: Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins. AUTHOR: Sazuka M; Imazawa H; Shoji Y; Mita T; Hara Y; Isemura M. AUTHOR AFFILIATION: School of Food and Nutritional Sciences, University of Shizuoka, Japan. SOURCE: Biosci Biotechnol Biochem 1997 Sep;61(9):1504-6NLM CIT. ID: 97480936 (abstract present)
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TITLE: Protective effect of green tea extract and tea polyphenols against the cytotoxicity of 1,4-naphthoquinone in isolated rat hepatocytes. AUTHOR: Miyagawa C; Wu C; Kennedy DO; Nakatani T; Ohtani K; Sakanaka S; Kim M; Matsui-Yuasa I. AUTHOR AFFILIATION: Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Japan. SOURCE: Biosci Biotechnol Biochem 1997 Nov;61(11):1901-5NLM CIT. ID: 98067855 (abstract present)
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TITLE: Effects of green tea, black tea and dietary lipophilic antioxidants on LDL oxidizability and atherosclerosis in hypercholesterolaemic rabbits. AUTHOR: Tijburg LB; Wiseman SA; Meijer GW; Weststrate JA AUTHOR AFFILIATION: Unilever Research Laboratorium, Vlaardingen, The Netherlands. Lilian.TijburgOURCE: Atherosclerosis 1997 Nov;135(1):37-47NLM CIT. ID: 98055649 (abstract present)
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TITLE: Effect of tea extracts, polyphenols, and epigallocatechin gallate on azoxymethane-induced colon cancer. AUTHOR: Weisburger JH; Rivenson A; Aliaga C; Reinhardt J; Kelloff GJ; Boone CW; Steele VE; Balentine DA; Pittman B; Zang E. AUTHOR AFFILIATION: Naylor Dana Institute, American Health Foundation, Valhalla, New York , USA. SOURCE: Proc Soc Exp Biol Med 1998 Jan;217(1):104-8NLM CIT. ID: 98081566 (abstract present)
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TITLE: Effects of theaflavins on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. AUTHOR: Morse MA; Kresty LA; Steele VE; Kelloff GJ; Boone CW; Balentine DA; Harbowy ME; Stoner GD. AUTHOR AFFILIATION: Division of Environmental Health Sciences, Ohio State University School of Public Health, Columbus , USA. morse.20OURCE: Nutr Cancer 1997;29(1):7-12NLM CIT. ID: 98045036 (abstract present)
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TITLE: [A preliminary study of the preventive and blocking effect of green tea grown in Mengding mountain area on the esophageal cancer in rats] AUTHOR: Wang C; Wang X; Li Y; Jiang Y; Deng S; Zhao M. AUTHOR AFFILIATION: Institute of Cancer Research, Chengdu.SOURCE: Hua Hsi I Ko Ta Hsueh Hsueh Pao 1996 Jun;27(2):206-8NLM CIT. ID: 98050428 (abstract present)
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TITLE: Protective effects of tea polyphenols against oxidative damage to red blood cells. AUTHOR: Grinberg LN; Newmark H; Kitrossky N; Rahamim E; Chevion M; Rachmilewitz EA. AUTHOR AFFILIATION: Department of Hematology, Hadassah University Hospital-Hebrew University Medical School, Jerusalem, Israel.SOURCE: Biochem Pharmacol 1997 Nov 1;54(9):973-8NLM CIT. ID: 98040573 (abstract present)
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TITLE: Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. AUTHOR: Chan MM; Fong D; Ho CT; Huang HI. AUTHOR AFFILIATION: Department of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia , USA. chanOURCE: Biochem Pharmacol 1997 Dec 15;54(12):1281-6NLM CIT. ID: 98053819 (abstract present) TITLE: Green tea and leukoplakia. The Indian-US Head and Neck Cancer Cooperative Group. SOURCE: Am J Surg 1997 Nov;174(5):552-5NLM CIT. ID: 98040392 (abstract present)
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TITLE: Inhibitory effect of green tea extract on the process of pancreatic carcinogenesis induced by N-nitrosobis-(2-oxypropyl)amine (BOP) and on tumor promotion after transplantation of N-nitrosobis-(2-hydroxypropyl)amine (BHP)-induced pancreatic cancer in Syrian hamsters. AUTHOR: Hiura A; Tsutsumi M; Satake K. AUTHOR AFFILIATION: First Department of Surgery, Osaka City University Medical School, Japan. SOURCE: Pancreas 1997 Oct;15(3):272-7NLM CIT. ID: 97477858 (abstract present)
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TITLE: Cancer-preventive effects of drinking green tea among a Japanese population. AUTHOR: Imai K; Suga K; Nakachi K. AUTHOR AFFILIATION: Department of Epidemiology, Saitama Cancer Center Research Institute, Japan. SOURCE: Prev Med 1997 Nov-Dec;26(6):769-75NLM CIT. ID: 98050142 (abstract present)
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TITLE: Hypocholesterolemic effects of Chinese tea. AUTHOR: Yang TT; Koo MW. AUTHOR AFFILIATION: Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong. SOURCE: Pharmacol Res 1997 Jun;35(6):505-12NLM CIT. ID: 98027222 (abstract present)
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TITLE: Possible mechanisms of antimutagens by various teas as judged by their effects on mutagenesis by 2-amino-3-methylimidazo[4,5-f]quinoline and benzo[a]pyrene. AUTHOR: Chen HY; Yen GC. AUTHOR AFFILIATION: Department of Food Science, National Chung Hsing University, Taichung, Taiwan, ROC.SOURCE: Mutat Res 1997 Sep 18;393(1-2):115-22NLM CIT. ID: 98020439 (abstract present)
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TITLE: Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea. AUTHOR: Conney AH; Lou YR; Xie JG; Osawa T; Newmark HL; Liu Y; Chang RL; Huang MT. AUTHOR AFFILIATION: Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway , USA.SOURCE: Proc Soc Exp Biol Med 1997 Nov;216(2):234-45NLM CIT. ID: 98007848 (abstract present)
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TITLE: Dietary differences with green tea intake among middle-aged Japanese men and women. AUTHOR: Tsubono Y; Takahashi T; Iwase Y; Iitoi Y; Akabane M; Tsugane S. AUTHOR AFFILIATION: Epidemiology and Biostatistics Division, National Cancer Center Research Institute, Kashiwa, Japan. SOURCE: Prev Med 1997 Sep-Oct;26(5 Pt 1):704-10NLM CIT. ID: 97468393 (abstract present)
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TITLE: [Effect of tea extracts, catechin and caffeine against type-I allergic reaction] AUTHOR: Shiozaki T; Sugiyama K; Nakazato K; Takeo T. AUTHOR AFFILIATION: Institute of Traditional Chinese Medicines, School of Pharmaceutical Sciences, University of Shizuoka, Japan. SOURCE: Yakugaku Zasshi 1997 Jul;117(7):448-54NLM CIT. ID: 97404493 (abstract present)
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TITLE: Effects of (-)-epigallocatechin-3-O-gallate (green tea tannin) on the life span of stroke-prone spontaneously hypertensive rats. AUTHOR: Uchida S; Ozaki M; Akashi T; Yamashita K; Niwa M; Taniyama K AUTHOR AFFILIATION: Research Laboratories, Yutoku Pharmaceutical Industrial Company, Kashima-shi, Saga, Japan. SOURCE: Clin Exp Pharmacol Physiol Suppl 1995;1:S302-3 NLM CIT. ID: 97076849
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TITLE: Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl salt-sensitive rats. AUTHOR: Abe Y; Umemura S; Sugimoto K; Hirawa N; Kato Y; Yokoyama N; Yokoyama T; Iwai J; Ishii M AUTHOR AFFILIATION: Second Department of Internal Medicine, Yokohama City University School of Medicine, Japan. SOURCE: Am J Hypertens 1995 Jan;8(1):74-9
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TITLE: Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats. AUTHOR: Yokogoshi H; Kobayashi M AUTHOR AFFILIATION: Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, University of Shizuoka, Yada, Japan. yokogosi SOURCE: Life Sci 1998;62(12):1065-8
Green Tea Research
TITLE: Cancer-preventive effects of drinking green tea among a Japanese population.AUTHOR: Imai K; Suga K; Nakachi KAUTHOR AFFILIATION: Department of Epidemiology, Saitama Cancer Center Research Institute, Japan.SOURCE: Prev Med 1997 Nov-Dec;26(6):769-75NLM CIT. ID: 98050142 ABSTRACT: BACKGROUND: Laboratory studies have revealed the cancer preventive effects of green tea, so the association between green tea consumption and cancer was examined in a human population. METHODS: The association between green tea consumption and cancer incidence was studied in our prospective cohort study of a Japanese population. We surveyed 8,552 individuals over 40 years of age living in a town in Saitama prefecture on their living habits, including daily consumption of green tea. During the 9 years of follow-up study (71,248.5 person-years), we identified a total of 384 cases of cancer in all sites. RESULTS: We found a negative association between green tea consumption and cancer incidence, especially among females drinking more than 10 cups a day. The slowdown in increase of cancer incidence with age observed among females who consumed more than 10 cups a day is consistent with the finding that increased consumption of green tea is associated with later onset of cancer. Age-standardized average annual incidence rate was significantly lower among females who consumed large amounts of green tea. Relative risk (RR) of cancer incidence was also lower among both females (RR = 0.57, 95% CI = 0.33-0.98) and males (RR = 0.68, 95% CI = 0.39-1.21) in groups with the highest consumption, although the preventive effects did not achieve statistical significance among males, even when stratified by smoking and adjusted for alcohol and dietary variables. CONCLUSION: Our epidemiological study showed that green tea has a potentially preventive effect against cancer among humans.
TITLE: Hypocholesterolemic effects of Chinese tea.AUTHOR: Yang TT; Koo MWAUTHOR AFFILIATION: Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong.SOURCE: Pharmacol Res 1997 Jun;35(6):505-12NLM CIT. ID: 98027222ABSTRACT: Chinese teas with different degrees of fermentation were examined for their effect on diet-induced hypercholesterolemia in rats. The teas tested were Chinese Green tea, Jasmine, Iron Buddha, Oolong and Pu erh. Hypercholesterolemia was induced by feeding rats with a cholesterol-enriched diet for 1 week. They were then treated with different tea extracts together with a cholesterol-enriched diet for another 8 weeks. Chinese Green tea and Jasmine tea, both with a minimum degree of fermentation, were found to have significant serum and liver cholesterol lowering effects. They also reduced the increase in liver weight due to lipid deposition. All tea treatments lowered the atherogenic index and increased the HDL-total cholesterol ratio, while HDL-cholesterol and triglyceride levels were not significantly affected. Analysis of catechin levels in tea extracts showed that the individual catechin component in Chinese Green tea and Jasmine tea were significantly higher than the others. (-)-Epicatechin gallate and (-)-epigallocatechin gallate in the tea extracts may account for their hypocholesterolemic effect.MAIN MESH SUBJECTS: Anticholesteremic Agents/*PHARMACOLOGY
TITLE: Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.AUTHOR: Ahmad N; Feyes DK; Nieminen AL; Agarwal R; Mukhtar HAUTHOR AFFILIATION: Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.SOURCE: J Natl Cancer Inst 1997 Dec 17;89(24):1881-6NLM CIT. ID: 98074987ABSTRACT:
BACKGROUND AND PURPOSE: The polyphenolic compounds present in green tea show cancer chemopreventive effects in many animal tumor models. Epidemiologic studies have also suggested that green tea consumption might be effective in the prevention of certain human cancers. We investigated the effect of green tea polyphenols and the major constituent, epigallocatechin-3-gallate, on the induction of apoptosis (programmed cell death) and regulation of cell cycle in human and mouse carcinoma cells. METHODS: Human epidermoid carcinoma cells (cell line A431), human carcinoma keratinocyte (cell line HaCaT), human prostate carcinoma cells (cell line DU145), mouse lymphoma cells (cell line L5178Y), and normal human epidermal keratinocytes (NHEKs) were used. Apoptosis was assessed by 1) the formation of internucleosomal DNA fragments by agarose gel electrophoresis, 2) confocal microscopy, and 3) flow cytometry after tagging the DNA fragments by fluorescence label. The distribution of cells in different phases of the cell cycle was analyzed by flow cytometry. RESULTS: Treatment of A431 cells with green tea polyphenols and its components, epigallocatechin-3-gallate, epigallocatechin, and epicatechin-3-gallate, resulted in the formation of internucleosomal DNA fragments, characteristic of apoptosis. Treatment with epigallocatechin-3-gallate also resulted in apoptosis in HaCaT, L5178Y, and DU145 cells, but not in NHEK. Confocal microscopy and flow cytometry confirmed the findings. The DNA cell cycle analysis showed that in A431 cells, epigallocatechin-3-gallate treatment resulted in arrest in the G0-G1 phase of the cell cycle and a dose-dependent apoptosis. CONCLUSIONS: Green tea may protect against cancer by causing cell cycle arrest and inducing apoptosis. It needs to be evaluated in human trials.
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